In addition to healthy monounsaturated fats, olive oil contains a natural compound called oleocanthal which may help prevent arthritis-related inflammation. This compound blocks the same inflammatory pathways as ibuprofen and aspirin, medications commonly used to fight arthritis pain. I recommend using olive oil when cooking instead of vegetable oil or butter (substitute in equal or lesser amounts). If you're also trying to lose weight to manage your arthritis, incorporate olive oil but be stingy with the amounts since all fat (including healthy fat like olive oil) is high in calories. For the highest antioxidant content, choose "extra virgin" olive oil; and note that the stronger the taste, the higher the amounts of oleocanthal the oil is likely to have.